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Antiviral Effect of Oryzacystatin, a Proteinase Inhibitor in Rice, Against Herpes Simplex Virus Type 1

A number of compounds, including organic solvents and detergents, are known to inactivate viruses [4]. Arch Dermatol 1999; 135:1393-1397. Previously, our lab has shown that blackberries, which are rich in phenolics, polyphenols, and flavonoids have antioxidant, anti-inflammatory and antiproliferative properties.22, 23 However, to our knowledge, scientific studies on the antiviral properties of blackberry extract have not been reported. The autophagy pathway includes several distinct forms of lysosomal degradation including macroautophagy, chaperone-mediated autophagy, and microautophagy. (Hypericaceae), Plantago coronopus L. Our data also suggest the importance of some thiol proteinases, which may be derived from either the host’s cells or HSV-1, during the replication process of HSV-1. 11, 12).

2003;14:824–828. After 1 hr incubation, cells were infected and monitored for cytopathic effect. HSK accounts for 20–48% of all recurrent ocular HSV infections leading to significant vision loss (Liesegang et al., 1989; Liesegang, 2001). (Hypericaceae), Plantago coronopus L. Virus stocks were propagated in Vero E6 cells and used at a concentration of 10 6.5 TCID 50 in all in vitro experiments. Cytotoxic chemotherapeutic agents are commonly used in disseminated KS with response rates of up to 80% (22, 59). The in vivo antiherpetic effect of OC-I was comparable to that of acyclovir, indicating that topical treatment of HSV-1 infection in humans with OC-I might be possible.

We found that propolis began to inhibit HSV-1 replication after 24 h of incubation and propolis activity against HSV-2 was found to start at 48 h following incubation. In addition to the interferon response, the autophagy pathway can play an important role in viral containment (Virgin and Levine, 2009). Treatment with DHEA 6 h before infection enhanced HSV-1 multiplication. Moreover, identification of the effective compound(s) within the extract would be necessary for future studies towards developing the new natural antiviral agent against HSV-1. In most tissues, the death of virally infected cells is a desired mode of virus containment. This may not be the complete list of references from this article. Copyright © 2004 John Wiley & Sons, Ltd.

Moreover, migration of CD8+ T cells to the liver in response to infection was impaired in CCR5−/− mice, and adoptive transfer of SCs from CCR5−/− mice infected for 6 days into newly infected wild-type mice did not improve antiviral activity in the liver, in contrast to what was seen in mice receiving immune SCs from wild-type mice. The replication of adenovirus 3 was not affected by MF. Solutions of 2.5, 5, and 10% Win 41258-3, applied to the skin starting 24 h postinfection, resulted in rapid suppression of development of herpetic vesicles and significant reduction of the virus titers in the lesion sites. Med. Ultra-pure preparations (>99% pure) were used to show that xanthohumol accounted for the antiviral activity observed in the xanthohumol-enriched hop extract against BVDV, HSV-1 and HSV-2. We inoculated 1×105 cells per ml and RPMI 1640 medium with 10% fetal calf serum into each well. Recently helicase-primase inhibitors, especially BAY 57-1293, have shown promising in vitro and in vivo activity against HSV-1.

The peptides were able to inhibit the entry of HSV-1 into the host cell, probably by blocking HS at the cell surface. Moving walls are generally represented in years. Further studies showed that thirteen of the tested extracts inhibited HSV-1 infection, some of which had a significant activity against this virus such as Senna podocarpa (Guill. administration of the CHCl3-soluble fraction at doses of 25 and 50 mg/kg or FK-3000 (1) at 10 and 25 mg/kg, similar results were obtained. The results indicated that mice infected with HSV-2 exhibited significant reduction in body weight, serious vulval lesions, massive lymphocyte invasion of vaginal tissue, and approximately 10⁴ copies/μl of HSV-2 were found in vaginal and uterine tissues. All 10 investigated mushroom species inhibited the reproduction of influenza virus strain A/FM/1/47 (H1N1) in MDCK cells reducing the infectious titer by 2.0-6.0 lg ID50. Nixon et al.

In the latter case, please turn on Javascript support in your web browser and reload this page. In the latter case, please turn on Javascript support in your web browser and reload this page. The need for new methods for the control and prevention of the virus is vital to reduce the number of people affected by HSV-1. ? Abstract:   (4534 Views) Background : Medicinal plants have been used for different diseases in past. Herpes Simplex Virus type 1 (HSV-1) antibodies are found in up to 90 percent of the general population. The antiviral activities of extracts from 5 species of marine algae collected at Haeundae (Pusan, Korea), were examined using plaque reduction assays.

Extracts from the aerial parts of the South African resurrection plant Myrothamnus flabellifolia Welw. Lectin is a protein that specifically bound and cross-linked with carbohydrates and involved in the activation of the lectin pathway which is considered a part of both innate and adaptive immunity. The antiviral activity of methylated alpha-lactalburnin (Met-ALA), methylated and ethylated beta-lactoglobulins (Met- and Et-BLG) was evaluated against acyclovir (ACV)-sensitive and -resistant strains of herpes simplex virus type 1 (HSV-1) and compared to that of ACV and L-polylysines (4-15 kDa) using fixed or suspended Vero cell lines.