Unexpectedly, B virus lacked a homolog of the HSV γ134.5 gene, which encodes a neurovirulence factor. The structural organization of the B virus genome is shown, with the UL and US regions represented by solid lines and the TRL, IRL, TRS, and IRS regions represented by open boxes. Unexpectedly, B virus lacked a homolog of the HSV gamma(1)34.5 gene, which encodes a neurovirulence factor. 23 additional cases described through 1973. The diagnostic sensitivities of the gB-, gC-, gD-, and mgG-ELISAs were 100, 97.3, 88.0, and 80.0%, respectively. Unexpectedly, B virus lacked a homolog of the HSV γ134.5 gene, which encodes a neurovirulence factor. Cercopithecine herpesvirus 1 (also called herpes B virus, herpesvirus simiae, or B virus [BV]) is an alphaherpesvirus that naturally infects macaque monkeys.
False negative and false positive results occur frequently in serologic tests for B virus, and serially collected serological data are often needed to confirm an animal’s disease status. Note: In calculating the moving wall, the current year is not counted. Apart from soft stool and splenic follicular hyperplasia, common findings with chronic SIV infection, no significant gross lesions were observed. Owing to the biosafety concerns, little research has been conducted directly using BV; most of the knowledge on this virus is extrapolated from study of its closely related viral species of the subfamily Alphaherpesvirinae, herpes simplex virus (HSV) type 1 (HSV-1) and HSV-2 . Furthermore, use of HBV antigens for serological assays is restricted to laboratories having high safety level (3-4). Non-vaccinated rabbits died within 8 days of challenge while 10/11 vaccinated animals were protected against herpes B virus disease. Hij wist immers dat exotische dieren zonder de goede papieren niet zomaar Nederland binnen mochten komen.
coli Rosetta (DE3). Note: In calculating the moving wall, the current year is not counted. At the emergency department (ED) of a medical center affiliated with the same university as the primate center, she informed the physician that she worked with nonhuman primates and may have been exposed to B virus. Briefly, herpes B virus infections in humans are rare with approximately 50 reported and 26 well documented cases worldwide. Herpes B (also known as Macacine herpesvirus 1 or Cercopithecine herpesvirus 1) is a virus carried by certain monkeys called macaques. Objectives: This study aimed to expressed the gD protein of BV in Escherichia coli by a recombinant vector, and prepare specific monoclonal antibodies against gD of BV to pave the way for effective and quick diagnosis reagent research. However, in 1997 a researcher died from B virus infection following a mucosal splash exposure.
They are like the known human herpesviruses and herpes simplex virus type 1, herpes simplex virus type 2, varicella-zoster, cytomegalovirus, Epstein-Barr virus, human herpesvirus 6, human herpesvirus 7 and, more recently, herpesvirus Kaposi’s sarcoma. The opposite transmission event—human to NHP—is less frequently reported. These results indicate that these alphaherpesviruses have differing preferences for entry receptors. Macacine herpesvirus 1, also known as B virus or herpes B virus and formerly as Cercopithecine herpesvirus 1, belongs to the family Herpesviridae, subfamily, Alphaherpesviridae. These results indicate that these alphaherpesviruses have differing preferences for entry receptors. The disease, usually a devastating infection of the central nervous system, occurs in humans and some primates that are not common hosts for this virus. About fifty cases of herpes B virus have been reported in the literature so far.
The specificities of the gB-, gC-, and gD-ELISAs and of the mgG-ELISA were 100 and 97.5%, respectively. Knowledge of the clinical signs and risk factors for human B-virus disease allows early initiation of antiviral therapy and prevents severe disease or death. The transcriptional control architecture is characterized by three key features: core transcription elements shared between genes, yielding divergent transcripts and a large number of coterminal transcripts; bifunctional transcriptional elements, yielding head-to-tail transcripts; and short repetitive sequences that could function as insulators against improperly terminated transcripts. Roizman, Proc. Dalrymple, A. When symptoms do occur, they are very similar to those caused by HSV. These results demonstrated that DNA immunization can be used to generate an immune response against a B virus glycoprotein in uninfected macaques.
The results of these studies are taken as evidence that poliomyelitis virus chiefly passes through a free extracellular phase before infecting new cells, while B virus may make use of an alternative route in which it is not exposed to the action of immune serum. Of all the simplex herpesviruses identified in non-human primates, only B virus is known to be pathogenic for humans. The virus is a member of the Alphaherpesvirus family (genus: Simplexvirus) and is closely related to the human herpes simplex virus (HSV). Some of the younger animals had undergone organ transplantation procedures, which included immunosuppression; the others had received no experimental manipulation. The neuronal precursor cell-expressed developmentally down-regulated 4 (Nedd4) family, comprised of nine members, is one of the main HECT E3 protein families.