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Prevalence of HIV-associated ophthalmic disease among patients enrolling for antiretroviral treatment in India: A cross-sectional

All patients with HZO should be seen by an ophthalmologist. There is a 40% homology in the nucleotide sequence between HIV-1 and HIV-2. The four major routes of transmission are unsafe sex, contaminated needles, breast milk, and transmission from an infected mother to her baby at birth (vertical transmission). Acquired immunodeficiency syndrome (AIDS) is caused by the human immunodeficiency virus (HIV) which affects all body organs either directly or by opportunistic infections, and the eye is not spared. Brain MRI showed increased T2 hyperintensity of old lesions and one new right frontal lesion, without contrast enhancement (Figure a). Iritis, epithelial and stromal keratitis have been reported. Opportunistic disease presentation differs according to different world regions as a result of different local prevalence of opportunistic agents.

In conclusion, our case shows that SS may occur within a dysimmune context that is possibly sustained by HIV infection, cART-associated immune reconstitution, or both. Ocular lesions usually occur in the late phase of HIV infection but can also be the presenting manifestation of the disease. HZO affects 5-15% of patients who have HIV. Résultats: L’âge moyen était de 35 ans avec un écart type de 11. 2000;33(1):45-8) in their study examined and followed up the ophthalmic conditions of a total of 274 HIV-infected patients. Its occurrence in a person below 50 years of age should arouse suspicion of immunosuppression. Oculocutaneous KS may precede, follow or develop concurrently with the visceral form and may involve the eyelid skin, conjunctiva, plica semilunaris, caruncle, lacrimal sac and rarely the lacrimal gland and orbit.


The study was approved by the Malawi College of Medicine research committee and the tenets of the Declaration of Helsinki were observed. For those who had available data, ocular syphilis was the presenting symptom of HIV infection in 28 out of 54 cases (52%). He was hospitalised and 0.1% Amphotericin B, 0.1% Propamidine isethionate and 0.02% Polyhexamethyl biguanide (PHMB) eye drops were instituted on an hourly basis. For those with evidence of immune reconstitution (elevated CD4+ T-lymphocyte counts, lower HIV blood levels), control of CMV retinitis becomes easier, and in many cases it is possible to discontinue specific anti-CMV therapy altogether. The life time risk of having at least one abnormal ocular lesion among HIV patients ranges from 52% to 100% [2–4]. A Mantoux test showed no induration (anergy). However, while the previous study was a large retrospective cohort study consisting of 1800 HIV-positive patients observed from 1984 to 1995 with 5200 person-years of follow-up, the average patient actually had less than 3 years of follow-up.2 Furthermore, whereas most HIV-positive patients in the original study developed AIDS during the study period,2 patients in our study have largely not been diagnosed as having AIDS.

Fluconazole has been found to be beneficial in the resolution of papilloedema caused by cryptococcal meningitis. The patient did not have hepatitis C and had therefore not been treated with alpha interferon. Out of the 125 patients, a total of 43 patients had ophthalmic manifestations. [3] According to National AIDS control organization (NACO, New Delhi), the number of HIV-positive patients in India was 5.2 million at the end of the of 2006, [4] and number of AIDS cases reported up to August 2006 were 124,995. The fundamentals of successful management of CMV retinitis are screening eye exams in patients with low CD4+ counts and effective anti-CMV treatment with ganciclovir and related compounds (valganciclovir), combined with potent antiretroviral therapy. Africa has the highest rate of HPV infection in the world, with an age-adjusted prevalence of 25.6% in women aged 15-74 years, followed by South America (14.3%), Asia (8.7%), and Europe (5.2%) [10]. Kaposi sarcoma is a painless mesenchymal-derived vascularized tumor that most often affects the skin and mucous membranes.

CONCLUSIONS: The incidence of Kaposi’s sarcoma has become very rare with the advent of HAART for HIV patients. With the improvement of access to antiretroviral treatment, the ocular complications of HIV/AIDS are more common. Conclusions: The incidence of HIV seropositivity doubled in the hospital over nearly 10-year period. Liesegang TJ. They are often mistaken for benign subconjunctival hemorrhage. Young adults presenting with HZO should be suspected of having HIV, and HIV-positive patients with HZO but HSN may still have ocular involvement. 52.33% had ocular lesions, of which the most frequent were cotton-like nodules (14.2%), retinal bleeding and Roth’s spots (8.5%), and ophthalmic herpes zoster (8.5%).

Any patient with signs or symptoms consistent with HIV infection or an opportunistic illness characteristic of AIDS should be tested for HIV. The only anterior segment disease found was a cataract with posterior synechiae (n=1) and the posterior segment pathologies were: a retinitis with vasculitis (n=1) and a papillary atrophy (n=2). Treatment of CMV retinitis with either foscarnet or ganciclovir was successful in initially controlling the retinitis. They were all receiving highly active anti retroviral therapy at the “Heart to Heart” clinic of the Niger Delta University Teaching Hospital (NDUTH).